4-Benzyloxy-2-methylphenylboronic acid, CAS 847560-49-0, is an arylboronic acid building block used to introduce a substituted phenyl group into organic molecules, commonly through palladium-catalyzed Suzuki–Miyaura coupling. Its structure combines a reactive boronic acid group with a benzyloxy substituent and a methyl group, making it relevant to synthetic chemistry programs that need those features in a defined arrangement. The reported molecular formula is C14H15BO3, with a molecular weight of approximately 242.08 g/mol. For purchasing, we recommend confirming identity, analytical documentation, packaging, availability, and lead time against your project requirements before placing an order.
This guide is intended for medicinal and process chemists, research organizations, fine-chemical buyers, and procurement teams evaluating CAS 847560-49-0. It is especially useful when a project requires a specific substituted aryl group and the buyer needs to assess whether this boronic acid is suitable for a planned synthesis. The guidance is also relevant to teams comparing supplier offers, defining a specification, or planning a scale-up inquiry. It does not replace reaction development, a product-specific certificate of analysis, or an assessment of local handling requirements.
The molecule contains an aryl–boronic acid functionality, which can act as a coupling partner in Suzuki–Miyaura chemistry under appropriate reaction conditions. In that transformation, the aryl group may be joined to a compatible electrophile, such as an aryl or heteroaryl halide, to form a carbon–carbon bond. The reaction outcome depends on the substrate pair, catalyst, base, solvent, temperature, and other conditions; the presence of a boronic acid alone does not guarantee a particular yield or conversion. The benzyloxy and methyl groups provide structural features that can be useful when the target molecule calls for them.
The benzyloxy group is an ether substituent that may be retained in a target structure or considered as a potential protecting-group handle, depending on the synthetic route. Its removal or transformation should be evaluated against the rest of the molecule because deprotection conditions can affect other functional groups. The methyl substituent is attached to the aromatic ring and influences the substitution pattern of the coupled product. Buyers should check positional identity carefully, since positional isomers may not be interchangeable in a structure-specific synthesis.
The most direct application is as a building block for cross-coupling routes in which the target requires the corresponding 4-benzyloxy-2-methylphenyl fragment. This may be relevant to discovery chemistry, preparation of reference compounds, and development of more complex organic intermediates. These are potential synthetic roles rather than claims that the material is approved for a particular end use or validated for a specific route. A chemist should confirm compatibility through literature review where available and experimental evaluation.
Before sourcing, map the compound to the exact bond-forming step in your synthesis. Confirm which atom or group on the coupling partner will react, whether the boronic acid is compatible with the planned catalyst system, and whether the benzyloxy group must remain intact. If the target requires a different substitution pattern or an unprotected phenol, this compound may not be the correct starting material. When the route is still under development, consider testing a small quantity before committing to a larger purchase.
For early screening, teams may choose an exploratory reaction scale such as 0.1–1 mmol, subject to their internal protocols and available material. This range is a planning example, not a recommended or guaranteed performance condition for this compound. Record the reagent lot, reaction conditions, and analytical results so that a successful experiment can be assessed for repeatability. Scale-up decisions should follow route-specific development and safety review.
State the product name and CAS number together in your inquiry, then request the available identity and quality documentation for the offered lot. Review the certificate of analysis, where available, for the test methods, reported results, and lot identification. Do not assume a purity value, appearance, or impurity profile from the chemical name alone. If your project requires a specific analytical method or acceptance threshold, communicate it before ordering.
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For example, a buyer might specify a target of 95% or 98% purity by a defined chromatographic method, but those figures are buyer-selected examples rather than a claim about Maison Chemical’s current stock. The method, calculation basis, and handling of water or residual solvents can affect how a reported result is interpreted. Ask whether the supplier’s available data can be compared directly with your internal criteria. If not, agree on the required testing or qualification approach before material release.
Estimate the amount needed for initial evaluation, repeat experiments, and any planned route-development work, while accounting for your organization’s inventory and handling procedures. Ask the supplier which pack sizes are currently available rather than assuming a standard minimum order quantity. Packaging should be suitable for the material and shipment conditions, with labeling that supports receipt, lot traceability, and internal control. Any special packaging or documentation requirement should be raised early because it may affect the quotation or schedule.
Price, minimum order quantity, and lead time are commercial terms that can vary with quantity, current availability, packaging, and destination. A low unit price may not be the most useful option if the offered pack size exceeds project needs or delivery timing does not fit the synthesis schedule. Request a written quotation that identifies the product, quantity, price basis, shipping terms, and estimated dispatch or delivery timing. Treat estimated lead times as supplier-confirmed information for the specific inquiry, not as a standing guarantee.
When comparing suppliers, evaluate both the material and the purchasing process. Request clear product identification and ask what documentation is available for the specific lot, such as a certificate of analysis and safety data sheet. Confirm that the quotation refers to CAS 847560-49-0 and that the offered specification aligns with your intended use. If the project has import, transport, or internal approval requirements, check those details before committing to an order.
A frequent mistake is purchasing by a shortened name without checking the CAS number and substitution pattern. Another is treating a general purity figure as sufficient without confirming the analytical method and whether the result meets the project’s own acceptance criteria. Buyers may also overlook the need to preserve the benzyloxy group during coupling or assume that a supplier’s availability estimate is a fixed delivery commitment. Clarifying these points before the order can reduce avoidable qualification and scheduling problems.
It is also important not to infer reaction suitability from a product specification alone. Even correctly identified material may behave differently across reaction systems, and conditions should be developed for the specific substrates and target. Where material quality is critical, define incoming inspection and retesting requirements with your technical and quality teams. Keep lot records with experimental results to support future procurement decisions.
At Maison Chemical, we support B2B inquiries for 4-Benzyloxy-2-methylphenylboronic acid CAS 847560-49-0 by reviewing the requested identity, quantity, documentation, packaging, and destination. Availability, commercial terms, and delivery timing should be confirmed for each quotation, since they depend on the specific order requirements. We can also discuss which product documents are available for review, including lot-related quality information where applicable. Providing your target quantity and required specification in the first inquiry helps us respond more efficiently.
4-Benzyloxy-2-methylphenylboronic acid CAS 847560-49-0 is a substituted arylboronic acid building block that may serve in Suzuki–Miyaura coupling routes when the target requires its specific aryl substitution pattern. Its suitability depends on the intended structure, reaction conditions, material specification, and handling of the benzyloxy group. For a sound sourcing decision, confirm identity and documentation, define your analytical and quantity requirements, and obtain current price and lead-time details before ordering. Contact Maison Chemical with your required quantity, specification, destination, and requested documents to begin a product inquiry.
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