2-Bromophenylboronic acid, identified by CAS 244205-40-1, is an aromatic boronic acid used primarily as a building block in organic synthesis. Its molecule combines a boronic acid group with an ortho-bromo-substituted phenyl ring, giving chemists two useful reaction handles in one intermediate. At Maison Chemical, we supply this compound for research, medicinal chemistry, process development, and other synthesis applications, subject to batch-specific availability and quality requirements.
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2-Bromophenylboronic acid is also known as 2-bromobenzeneboronic acid or (2-bromophenyl)boronic acid. Its molecular formula is C6H6BBrO2, and its calculated molecular weight is approximately 200.83 g/mol. The compound contains both an aryl bromide and a boronic acid functionality, which is the main reason it is valuable as a multifunctional synthetic intermediate.
The “2-bromo” designation means that the bromine atom and boronic acid group occupy adjacent positions on the benzene ring. This ortho relationship can influence steric effects, reaction rates, regioselectivity, and the design of downstream molecules. Because these effects depend on the reaction system, I recommend evaluating the material together with the intended catalyst, solvent, base, temperature, and scale rather than treating the name alone as a performance guarantee.
The best-known function of 2-bromophenylboronic acid is participation in Suzuki–Miyaura cross-coupling reactions. In a typical coupling, the boronic acid group reacts with an aryl or vinyl halide in the presence of a suitable palladium catalyst and base, allowing formation of a new carbon–carbon bond. The exact conversion and selectivity depend on substrate structure and process conditions, so a small-scale compatibility test is prudent before larger procurement.
The aryl bromide can remain available for subsequent transformation or can be used as the electrophilic site in a suitably designed sequence. This creates opportunities for sequential or chemoselective synthesis, although the order of reactions must be selected carefully. In practice, chemists may use the compound to prepare substituted biaryls, heteroaryl derivatives, pharmaceutical intermediates, agrochemical research compounds, and advanced materials intermediates.
Research laboratories use 2-Bromophenylboronic acid when they need an aromatic fragment that can be connected to another organic group through cross-coupling. Medicinal chemistry teams may evaluate it during the preparation of small libraries containing substituted biphenyl, heteroaryl, or fused-ring structures. Process development groups may also assess it as a route intermediate when a brominated aromatic precursor offers useful flexibility for later functionalization.
This material is generally better suited to synthesis than to direct formulation use. It should not be selected as an active ingredient, finished-product component, or process aid without appropriate technical and regulatory review. I also advise buyers to confirm whether the intended application requires research grade, high-assay material, or a custom specification.
2-Bromophenylboronic acid is commonly supplied as a solid, but the exact appearance can vary with particle size, packaging, storage history, and batch condition. Boronic acids may be sensitive to moisture and can undergo changes in form or purity if exposed to unsuitable environmental conditions for extended periods. For that reason, I recommend keeping the container tightly closed, minimizing repeated exposure to humid air, and following the supplier’s current safety data sheet.
Although the molecular weight is approximately 200.83 g/mol, other physical data such as melting behavior, water solubility, and appearance should be confirmed against the specific lot documentation. Published and commercial descriptions can differ because of measurement methods, crystal form, residual solvent, and purity criteria. Buyers should therefore treat catalog values as indicative unless they are supported by a current certificate of analysis or technical specification.
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Storage temperature should be selected from the supplier’s validated recommendation rather than assumed from the chemical name. Some buyers request refrigerated storage, such as 2–8 °C, but this should be confirmed for the specific product, packaging, and transport route. I recommend recording the received condition, lot number, opening date, and storage conditions as part of normal laboratory or manufacturing controls.
A useful purchasing specification should cover identity, purity, physical form, packaging, and documentation. For many research applications, an assay target of 98% or higher may be requested, but the required level depends on the reaction, impurity profile, and downstream risk. A high assay alone does not replace confirmation of water content, residual solvents, trace metals, or other impurities when these factors can affect a sensitive process.
| Specification area | What to confirm | Why it matters |
|---|---|---|
| Identity | CAS 244205-40-1, name, formula, and molecular weight | Prevents substitution or documentation mismatch |
| Purity | Assay method, stated purity, and impurity profile | Supports reproducible reaction screening |
| Physical form | Solid appearance, particle characteristics, and packing format | Improves weighing, transfer, and process planning |
| Documentation | Certificate of analysis, SDS, and lot traceability | Supports internal quality and safety review |
| Supply terms | MOQ, lead time, packaging, and shipping conditions | Reduces procurement and scheduling risk |
Depending on the project, I can help buyers define additional tests before quotation. These may include water content, elemental impurities, residual solvents, chromatographic purity, or identity confirmation by appropriate analytical techniques. The final acceptance criteria should be agreed before order placement so that the supplied batch can be evaluated against the same standard used by the customer.
For early reaction screening, a practical package size and reliable identity documentation may be more important than a highly customized specification. For route development or scale-up, buyers usually need stronger lot consistency, defined analytical methods, stable packaging, and a clear replenishment plan. I recommend reassessing the specification when moving from discovery chemistry to process development because the most important quality attributes may change.
When comparing suppliers, review more than the listed price per gram. Ask whether the supplier can provide a current COA, SDS, lot traceability, export documentation, packaging details, and realistic lead-time information. It is also useful to confirm whether the supplier can support repeat orders or discuss custom quantities when the project moves beyond laboratory scale.
Maison Chemical supports B2B sourcing of 2-Bromophenylboronic acid CAS 244205-40-1 with product identification review, specification discussion, quotation support, and export coordination. We do not present a generic specification as a substitute for batch documentation. Instead, we work with buyers to clarify required purity, quantity, packaging, destination, and documentation before confirming the most suitable supply option.
In direct answer to the question, 2-Bromophenylboronic acid CAS 244205-40-1 is a multifunctional aromatic building block used mainly to construct substituted organic molecules through cross-coupling and related synthetic routes. Its value comes from combining an aryl boronic acid group with an adjacent aryl bromide, while its suitability depends on the reaction design, purity requirement, and handling conditions. It is therefore best evaluated as a project-specific chemical intermediate rather than as a one-size-fits-all material.
Before purchasing, define the required quantity, assay, analytical documentation, packaging, storage expectations, destination, and delivery schedule. Then request a batch-specific COA and confirm whether the proposed specification matches your reaction and quality system. For a quotation or supply discussion, contact Maison Chemical with your CAS number, target quantity, required purity, packaging preference, and delivery location so we can prepare a practical B2B sourcing proposal.
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